Publications - Duke O'Brien Center for Kidney Research

Users of the DOCK should use the following statement in any publication or presentation-

"Research reported in this publication was supported by the National Institute of Diabetes, Digestive and Kidney Diseases of the National Institutes of Health under Award Number P30DK096493"


Fritz KS1, Green MF, Petersen DR, Hirschey MD. Ethanol metabolism modifies hepatic protein acylation in mice. PLoS One. 2013 Sep 20;8(9) PMID:  24073283, PMCID:  PMC3779192.

Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, Uechi G, Beck ME, Rardin MJ, Vockley J, Verdin E, Gibson BW, Hirschey MD, Goetzman ES. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem. 2013 Nov 22;288(47):33837-47. PMID:  24121500, PMCID:  PMC3837126.


Dimke H, Sparks MA, Thomson BR, Frishe S, Coffman TM, Quaggin SE. Tubulovascular Cross-Talk by Vascular Endothelial Growth Factor A Maintains Peritubular Microvasculature in Kidney. J Am Soc Nephrol. 2014 Nov 10 PMID: 25385849, PMCID:  PMC4413754.

Wysocki J1, Ortiz-Melo DI, Mattocks NK, Xu K, Prescott J, Evora K, Ye M, Sparks MA, Haque SK, Batlle D, Gurley SB. ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney. Physiol Rep. 2014 Mar 24;2(3) PMID:  24760518, PMCID:  PMC4002244.

Tan M et al. Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab. 2014 Apr 1;19(4):605-17. PMID:  24703693, PMCID:  PMC4108075.

Pálsson R, Patel UD. Cardiovascular complications of diabetic kidney disease. Adv Chronic Kidney Dis. 2014 May;21(3):273-80. PMID:  24780455, PMCID:  PMC4045477.

Wang L, Tang Y, Eisner W, Sparks MA, Buckley AF, Spurney RF. Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. Biochem Biophys Res Commun. 2014 Feb 21;444(4):622-7. PMID:  24491571, PMCID:  PMC3985087.

Inrig JK, Califf RM, Tasneem A, Vegunta RK, Molina C, Stanifer JW, Chiswell K, Patel UD. The landscape of clinical trials in nephrology: a systematic review of Am J Kidney Dis. 2014 May;63(5):771-80. PMID:  24315119, PMCID:  PMC3988265.

Ortiz-Melo DI, Spurney RF. Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen. Kidney Int. 2014. May;85(5):1009-11. PMID:  24786873.

Zhang JD, Patel MB, Griffiths R, Dolber PC, Ruiz P, Sparks MA, Stegbauer J, Jin H, Gomez JA, Buckley AF, Lefler WS, Chen D, Crowley SD. Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis. J Clin Invest. 2014. May;124(5):2198-203. PMID:  24743144PMCID:  PMC4001526.

Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. J Am Soc Nephrol. 2014 Sep;25(9):1991-2002. PMID: 24676636, PMCID: PMC4147982.

Gbadegesin RA, Adeyemo A, Webb NJ, Greenbaum LA, Abeyagunawardena A, Thalgahagoda S, Kale A, Gipson D, Srivastava T, Lin JJ, Chand D, Hunley TE, Brophy PD, Bagga A, Sinha A, Rheault MN, Ghali J, Nicholls K, Abraham E, Janjua HS, Omoloja A, Barletta GM, Cai Y, Milford DD, O'Brien C, Awan A, Belostotsky V, Smoyer WE, Homstad A, Hall G, Wu G, Nagaraj S, Wigfall D, Foreman J, Winn MP, Members of the Mid-West Pediatric Nephrology Consortium. HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome. J Am Soc Nephrol. 2014 Oct 27.  PMID:  25349203, PMCID:  PMC4483579.

Malone AF, Phelan PJ, Hall G, Cetincelik U, Homstad A, Alonso AS, Jiang R, Lindsey TB, Wu G, Sparks MA, Smith SR, Webb NJ, Kalra PA, Adeyemo AA, Shaw AS, Conlon PJ, Jennette JC, Howell DN, Winn MP, Gbadegesin RA. Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney Int. 2014 Dec;86(6):1253-9. PMID:  25229338, PMCID:  PMC4245465.

Patel UD.  Outcomes after pediatric kidney transplantation improving:  how can we do even better?  Pediatrics 2014 Apri;133(4):734-5.  PMID:  24616364, PMCID: PMC3966509.


Kommaddi RP, Jean-Charles PY, Shenoy SK. Phosphorylation of the Deubiquitinase USP20 by Protein Kinase A Regulates Post-endocytic Trafficking of β2 Adrenergic Receptors to Autophagosomes during Physiological Stress. J Biol Chem. 2015 Apr 3;290(14):8888-903. PMID: 25666626. PMCID: PMC4423680

Sparks MA, Stegbauer J, Chen D, Gomez JA, Griffiths RC, Azad HA, Herrera M, Gurley SB, Coffman TM. Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. J Am Soc Nephrol. 2015 Apr 8.  PMID: 25855778. PMCID: PMC4657834

Chen D, Coffman TM.  AT1 angiotensin receptors-vascular and renal epithelial pathways for blood pressure regulation.  Curr Opin Pharmacol.  2015 Sep;14(9):2308-15.  PMID: 25687370

Hirschey MD, Zhao Y.  Metabolic regulation by lysine malonylation, succinylation, and glutarylation.  Mol Cell Proteomics.  2015 Sep;14(9):2308-15.  PMID: 25717114. PMCID: PMC4563717

Stanifer JW, Karia F, Voils CI, Turner EL, Maro V, Shimbi D, Kilawe H, Lazaro M, Patel UD.  Development and validation of a cross-cultural knowledge, attitudes, and practices survey instrument for chronic kidney disease in a Swahili-speaking population.  PLoS One.  2015 Mar 26; 10(3).  PMID:  25811781, PMCID:  PMC4374886.

Anderson BR, Howell DN, Soldano K, Garrett ME, Katsanis N, Telen MJ, Davis EE, Ashley-Koch AE.  In vivo modeling implicates APOL1 in nephropathy:  evidence for dominant negative effects and epitasis under anemic stress.  PLoS Genet.  2015 Jul 6;11(7).  PMID: 26147622

Johnson SA, Spurney RF.  Twenty years after ACEIs and ARBs:  emerging treatment strategies for diabetic nephropathy.  Am J Physiol Renal Physiol.  2015 Nov 15;309(102015):F807-20.  PMID:  26336162.  PMCID:  PMC4652076


Madan B, Patel MB, Zhang J, Bunte RM, Rudemiller NP, Griffiths R, Virshup DM, Crowley SD.  Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.  Kidney Int.  2016 May;89(5):1062-74.  PMID:  27083283.  PMCID:  PMC4834146

Chen D, Stegbauer J, Sparks MA, Kohan D, Griffiths R, Herrera M, Gurley SB, Coffman TM.  Impact of angiotensin type 1A receptors in principal cells of the collecting duct on blood pressure and hypertension.  Hypertension.  2016 Jun;67(6):1291-7.  PMID: 27141055. PMCID: PMC4865430

Tyson CC, Lin P-H, Corsino L, Batch BC, Allen J, Sapp S, Barnhart H, Nwankwo C, Burroughs J, Svetkey LP.  Short-term effects of the DASH diet in adults with moderate chronic kidney disease:  a pilot feeding study.  Clin Kidney J.  2016 Jun.  PMID: 27478603

Foster MH.  Basement membranes and autoimmune diseases.  Matrix Biol.  2016 Aug 2.  Review.   PMID: 27496347 

Foster MH.  Optimizing the translational value of animal models of glomerulonephritis:  insights from recent murine protoptypes.  Am J Physiol--Renal.  2016 Sep 1;311(3):F487-95.  Review.  PMID: 27335377.  PMCID:  PMC5142166

Rudemiller NP, Patel MB, Zhang JD, Jeffs AD, Karlovich NS, Griffiths R, Kan MJ, Buckley AF, Gunn MD, Crowley SD.  C-C motif chemokine 5 attentuates angiotensin II-dependent kidney injury by limiting renal macrophage infiltration.  Am J Pathol.  2016 Nov;186(11):2846-2856.  PMID: 27640148.  PMCID:  PMC5222967.  PMCID:  PMC5222967

Crowley SD, Jeffs AD.  Targeting cytokine signaling in salt-sensitive hypertension.  Am J Physiol--Renal.  2016 Dec 1;311(6):F1153-F1158.  PMID: 27558557.  PMCID:  PMC5210191

Foley FB, Steinberg DM, Levine EL, Askew S, Batch BC, Puleo E, Svetkey LP, Bosworth HB, DeVries A, Miranda H, Bennett GG.  Track:  a randomized controlled trail of a digital health obesity treatment intervention for medically vulnerable primary care patients.  Contemporary Clinical Trials.  2016;48:12-20.  PMID:  26995281

Michels WM, Jaar BG, Ephraim PL, Liu Y, Miskulin DC, Tangri N, Crews DC, Scialla JJ, Shafi T, Sozio SM, Bandeen-Roche K, Cook CJ, Meyer KB, Boulware LE; DEcIDE Network Patient Outcomes in End Stage Renal Disease Study investigators.  Intravenous iron administration strategies and anemia management in hemodialysis patients.  Nephrol Dial Transplant.  2016 Sept 6.  PMID: 27604984

Pun PH, Sheng S, Sanders G, DeVore AD, Friedman D, Fonarow GC, Heidenreich PA, Yancy CW, Hernandez AF, Al-Khatib SM.  Prescription of guideline-recommended implantable cardioverter defibrillator and cardiac resynchronization therapy among patients hospitalized with heart failure and varying degrees of renal function.  Am J Cardiol.  2016 Dec 16.  PMID: 28160975

Wu M, Zhang JD, Tang RN, Crowley SD, Liu H, Lv LL, Ma KL, Liu BC.  Elevated PTH induces endothelial to chondrogenic transition in aortic endothelial cells.  Am J Physiol--Renal.  2016.  (In Press)



Hall G, Lane B, Chryst-Ladd M, Wu G, Lin JJ, Qin X, Hauser ER, Bgadegesin R.  Dysregulation of WT1 (1KTS) is associated with the kidney-specific effects of the LMX1B R246Q mutation.  Sci Rep.  2017 Jan 6;7:39933.  PMID: 28059119.  PMCID:  PMC5216339

Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH.  Renal collectrin protects against salt-sensitive hypertension and is downregulated by angiotensin II.  J Am Soc Nephrol.  2017 Jan 6.  PMID: 28062568

Lopez-Rivera E, et al.  Genetic drivers of kidney defects in the DiGeorge Syndrome.  N Engl J Med.  2017 Jan 25.  PMID: 28121514

Brown LA, Sofer T, Stilp AM, Baier LJ, Kramer HJ, Masindova I, Levy D, Hanson RL, Moncrieft AE, Redline S, Rosas SE, Lash JP, Cai J, Laurie CC, Browning S, Thornton T, Franceschini N.  Admixture mapping identifies an Amerindian ancestry locus associated with albuminuria in Hispanics in the United States.  J Am Soc Nephrol.  January 30, 2017.  PMID: 28137830

El Husseini N, Fonarow GC, Smith EE, Ju C, Schwamm LH, Hernandez AF, Schulte PJ, Xian Y, Goldstein LB.  Renal dysfunction is associated with poststroke discharge disposition and in-hospital mortality:  findings from Get with the Guidelines-Stroke.  Stroke.  2017 Feb;48(2):327-334.  PMID: 28034963.  PMCID:  PMC5268130

Chatterjee R, Davenport CA, Svetkey LP, Batch BC, Lin PH, Ramachandran VS, Fox ER, Harman J, Yeh HC, Selvin E, Correa A, Butler K, Edelman D.  Serum potassium is a predictor of incident diabetes in African Americans with normal aldosterone:  the Jackson Heart Study (JHS).  Am J Clin Nutr.  2017 Feb;105(2):442-449.  PMID: 27974310. PMCID: PMC5267306

Munoz-Mendoza J, Isakova T, Cai X, Faul C, Bayes LY, Scialla JJ, Lash JP, Chen J, He J, Navaneethan S, Negrea L, Rosas S, Kretzler M, Nessel L, Xie D, Anderson AH, Raj D, Wolf M; CRIC Study investigators.  Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease:  The CRIC Study.  Kidney Int.  2017 March;91(3):711-719.  PMID: 28017325. PMCID: PMC5313324

Samuel-Hodge CD, Holder-Cooper JC, Gizlice Z, Davis G, Steele SP, Keyserling TC, Kumanyika SK, Brantley PJ, Svetkey LP.  Family Partners in Lifestyle Support (PALS):  family-based weight loss for African American adults with type 2 diabetes.  Obesity (Silver Spring).  2017 Jan;25(1):45-55.  PMID: 27911049. PMCID: PMC5182111

Shafi T, Sozio SM, Luly J, Bandeen-Roche KJ, St. Peter WL, Ephraim PL, McDermott A, Herzog CA, Crews DC, Scialla JJ, Tangri N, Miskulin DC, Michels WM, Jaar BG, Zager PG, Meyer KB, Wu AW, Boulware LE; DEcIDE Network Patient Outcomes in End Stage Renal Disease Study Investigators.  Antihypertensive medications and risk of death and hospitalizations in US hemodialysis patients:  evidence from a cohort study to inform hypertension treatment practices.  Medicine.  2017 Feb;96(5):e5924.  PMID: 28151871. PMCID: PMC5293434

Scialla JJ, Asplin J, Dobre M, Chang A, Lash J, Hsu CY, Kallem RR, Hamm L, Feldman H, Chen J, Appel L, Anderson CM, Wolf M.  Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes.  Kidney Int.  2017;91:204-15.  PMID: 27914710

Crowley SD, Rudemiller NP.  Immunological effects of the renal angiotensin system.  JASN.  2017.  (In Press)

Vemulapalli S, Luqin D, Patel MR, Kilgore M, Jones WS, Curtis LJ, Irvin MR, Svetkey LP, Shimbo D, Calhoun DA, Muntner P.  National patterns in intensity and frequency of outpatient care for apparent treatment-resistant hypertension.  Am Heart J.  2017.  (In Press)

Roberts JK, Rao SV, Shaw LK, Gallup DS, Marroquin OC, Patel UD.  Comparative efficacy of coronary revascularization procedures for multivesse coronary artery disease in patients with chronic kidney disease.  Am J Cardiol.  2017.  (In Press)

Coffman T, Stegbauer J, Gurley S, Chen D, Sparks M, Yang T, Herrera M.  Resistance to hypertension mediated by intercalated cells of the collecting duct.  J Clin Invest Insight.  2017.  (In Press)

Wang H, Pun PH, Kwee L, Craig D, Haynes C, Chryst-Ladd M, Svetkey LP, Patel UD, Hauser ER, Pollak M, Kraus WE, Shah SH.  Apolipoprotein L1 genetic variants are associated with chronic kidney diseawse but not cardiovascular disease in a population referred for cardiac catheterization.  CardioRenal Med.  2017.  (In Press)