Pilots - Duke O'Brien Center for Kidney Research

The Pilot and Feasibility (P&F) Program of the Duke O’Brien Center for Kidney Research (DOCK) is designed to enhance the ability of investigators to explore a concept related to the Center’s areas of emphasis with the long-term goal of generating sufficient data to pursue the concept through other funding mechanisms. The Program supports applicants from the existing biomedical research community at Duke University Medical Center and provides research support for a limited time (one to two years) to selected applicants who meet one of the following eligibility criteria:

  • Early stage investigators without current or past NIH research support (R01, P01) as a project director/principal investigator (current or past support from other sources should be modest).
  • Established investigators with no previous work in kidney disease who wish to apply their expertise to a problem in the Center’s areas or emphasis.
  • Established investigators who propose testing innovative ideas related to the Center’s research theme and that represent a clear departure from ongoing research.

2016 Awardees

Svati Shah, MD
Department of Medicine, Division of Cardiology, DUMC
"Identification of Novel Genetic, Metabolomic and Other 'Omic Cardiovascular Phenotypes Using the Duke Cardiac Catheterization Lab (CATHGEN) Biorepository"

Christopher Kontos, MD
Department of Medicine, Division of Cardiology, DUMC
"Sex-Dependence of the Role of Caskin2 in Cardiovascular and Metabolic Disease"

Jen-Tsan Ashley Chi, PhD
Department of Molecular Genetics and Microbiology, DUMC
Control of Nrf2-Signaling in Podocytes through Glucose-Induced Glycosylation"

2015 Awardees

Sudarshan Rajagopal, MD, PhD
Department of Medicine, Division of Cardiology, DUMC
"Targeting Vascular Endothelin Beta Arrestin Signaling in Hypertension"

Gentzon Hall, MD, PhD
Department of Medicine, Division of Nephrology, DUMC
"Novel Gene Discovery in African Americans with Hereditary Focal Segmental Glomerulosclerosis"

Julia Scialla, MD, MHS
Department of Medicine, Divisoin of Nephrolgoy, DUMC
"Ammoniagenesis and Vascular Function in Chronic Kidney Disease"


2014 Awardees

Julia Scialla, MD, MHS
Department of Medicine, Division of Nephrology, DUMC
Ammoniagenesis, Net Acid Excretion and Vascular Function in DASH

Sudha Shenoy, PhD
Department of Medicine, Division of Cardiology, DUMC
Role of USP20 in Kidney and Cardiac Function

Michael Ross, MD
Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine
"Role of the Ubiquitin-Like Protein FAT10 in Cardiovascular and Kidney Injury"


2013 Awardees

Beverly Koller, PhD
University of North Carolina- Chapel Hill
Novel Models to Define Genetic Mechanisms of Kidney Disease Susceptibility in African-Americans

Crystal Tyson, MD
Department of Medicine, Division of Nephrology, DUMC
"Effects of the Dietary Approaches to Stop Hypertension Eating Pattern (DASH) on Blood Pressure and Serum Electrolytes in Patients with Moderate Kidney Disease: A Pilot Study"

Svati H. Shah, MD, MHS
Department of Medicine, Division of Cardiology, DUMC
"Endoplasmic Reticulum Stress Markers and Incident Development of Kidney Disease in Patients with Coronary Artery Disease: An Integrated Molecular Approach"

Matthew D. Hirschey, PhD
Department of Medicine, Division of Endocrinology, Nutrition, and Metabolism, DUMC
"Identifying the Role of SIRT5 on Renal and Cardiac Function"


2012 Awardees

Rasheed Gbadegesin, MD
Assistant Professor of Pediatrics and Medicine, DUMC
Duke University Medical Center
“Identification of new autosomal recessive FSGS genes by linkage analysis and whole exome sequencing”

Patrick Pun, MD
Assistant Professor of Medicine, Division of Nephrology, DUMC
 “Pro-Arrhythmic Genotypes and Sudden Cardiac Death Risk in CKD Patients”

Detailed Description of Pilot & Feasibility Program
NIH Biosketch Form