Clinical and Translational Core - Duke O'Brien Center for Kidney Research

Chronic kidney disease is both a cause and consequence of hypertension (HTN), and both CKD and HTN are independent risk factors for cardiovascular disease (CVD). Thus CKD, CVD and HTN are closely inter-related (Figure), and the investigation of each in relation to the others holds the greatest promise for improving the public health.

Interested in obtaining samples or data from clinical trial or registries? Take a look at the DOCK data and sample inventory.

2012-2013 Funded Projects

2013-2014 Funded Projects

2014-2015 Funded Projects

2015-2016 Funded Projects

 

We believe that clinical and translational research can advance understanding of these inter-relationships by evaluating the relevance of basic science discoveries to these conditions in humans, and by identifying associations in humans that warrant validation in biological systems.

The Clinical and Translational Core of the Duke O'Brien Center for Kidney Research (DOCK) builds on an outstanding track record of human research in CKD, CVD and HTN. Individual investigators studying kidney disease (KD), CVD, or HTN often recognize the need to consider all three conditions, but are often limited by lack of access to these resources. The DOCK Clinical and Translational Core will encourage and facilitate expansion of each area into multi-disciplinary research that addresses our thematic focus: to promote and support research into understanding the unique links among KD, CVD, and HTN.

This Core will focus specifically on investigating pathophysiology, epidemiology, and therapeutic response in on-going studies or existing datasets that focus on one condition but that would provide deeper insight by expanding the focus to include each of the others. In this way, the Core will lead to a greater understanding of these interrelationships that may ultimately lead to more effective interventions to prevent or halt the adverse health outcomes from KD, CVD, and HTN.

The Clinical and Translational Core will capitalize on existing relationships of investigators in Duke Nephrology with the Duke Translational Medicine Institute (DTMI), the Duke Clinical Research Institute (DCRI), and other entities at Duke.

The DOCK Clinical and Translational Core provides:

  • A study implementation group that:
    • reviews and prioritizes projects by Core investigators to be supported by Core resources upon selection by the Executive Committee, click here for more information and see who is currently funded;
    • evaluates specific needs within the Core for each selected project or investigator;
    • assists and guides the planning, development, implementation and coordination of study protocols, including Institutional Review Board approval, data management, and overall project management; and
    • assists the Core investigators with establishing appropriate scientific input and access to additional resources.
  • A biostatistics unit that provides Core investigators with access to doctoral- and masters-level statistical support for study design and data analyses.
  • A biological samples unit that provides Core investigators with access to existing sample repositories and assistance using these repositories.
  • A database unit that provides access to existing clinical data repositories, and support to acquire and store additional datasets as necessary.

These resources will provide foundational clinical and translational research support for a wide range of research approaches. Thus, the Clinical and Translational Core will promote powerful interdisciplinary research that will move science forward in addressing the inter-relationships among KD, CVD and HTN.

Clinical and Translational Core

 

 

 

 

 

 

 

 

 

Figure. Inter-relationships between KD, CVD, HTN. Areas of Core focus will be on the pathophysiology, epidemiology and therapeutic responses that inform our understanding of the: 1) factors that affect risk, initiation, and progression of KD; 2) impact of KD on CVD and HTN; and 3) impact of CVD and HTN on KD. [abbreviations: KD, kidney disease; CKD, chronic kidney disease; AKI, acute kidney injury; ESRD, end-stage renal disease; HTN, hypertension; CAD, coronary artery disease; ACS, acute coronary syndrome; LVH, left-ventricular hypertrophy; CHF, congestive heart failure.